This work is licensed under a Creative Commons Attribution 4.0 International License.
ATSP-1800
General Information
DRACP ID DRACP05901
Peptide Name ATSP-1800
Sequence QSQQTFⓍNLWRLLⓍQN
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=25.9 nM; MDMX: Ki=105.7 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(7)=R8; Ⓧ(14)=S5
Chiral L
Physicochemical Information
Formula C79H118N24O21
Absent amino acids ACDEGHIKMPVY
Common amino acids Q
Mass 200769
Pl 10.55
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Net charge 1
Boman Index -3626
Hydrophobicity -85.63
Aliphatic Index 73.13
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.