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ATSP-3848
General Information
DRACP ID DRACP05902
Peptide Name ATSP-3848
Sequence LTFEHYWAQLTS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=14.6 nM; MDMX: Ki=47.4 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H98N16O20
Absent amino acids CDGIKMNPRV
Common amino acids LT
Mass 169204
Pl 5.36
Basic residues 1
Acidic residues 1
Hydrophobic residues 5
Net charge 0
Boman Index -873
Hydrophobicity -20
Aliphatic Index 73.33
Half Life
Mammalian: 0.8 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.