This work is licensed under a Creative Commons Attribution 4.0 International License.
ATSP-3900
General Information
DRACP ID DRACP05903
Peptide Name ATSP-3900
Sequence LTFⓍHYWAQLⓍS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=1 nM; MDMX: Ki=18.3 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(4)=R8; Ⓧ(11)=S5
Chiral L
Physicochemical Information
Formula C62H80N14O13
Absent amino acids CDEGIKMNPRV
Common amino acids L
Mass 142579
Pl 7.54
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Net charge 1
Boman Index 65
Hydrophobicity 15
Aliphatic Index 73.33
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.