This work is licensed under a Creative Commons Attribution 4.0 International License.
ATSP-4641
General Information
DRACP ID DRACP05904
Peptide Name ATSP-4641
Sequence LTFⓍAYWAQLⓍS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=4.9 nM; MDMX: Ki=34.3 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(4)=R8; Ⓧ(11)=S5
Chiral L
Physicochemical Information
Formula C59H78N12O13
Absent amino acids CDEGHIKMNPRV
Common amino acids AL
Mass 135973
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 6
Net charge 0
Boman Index 712
Hydrophobicity 56.67
Aliphatic Index 81.67
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.