This work is licensed under a Creative Commons Attribution 4.0 International License.
ATSP-6935
General Information
DRACP ID DRACP05905
Peptide Name ATSP-6935
Sequence LTFⓍEYWAQLⓍS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=1.2 nM; MDMX: Ki=8 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(4)=R8; Ⓧ(11)=S5
Chiral L
Physicochemical Information
Formula C61H80N12O15
Absent amino acids CDGHIKMNPRV
Common amino acids L
Mass 141776
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 5
Net charge -1
Boman Index -150
Hydrophobicity 12.5
Aliphatic Index 73.33
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.