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PMI-HIF1-2
General Information
DRACP ID DRACP05909
Peptide Name PMI-HIF1-2
Sequence TSFAEYWALLSXLAXYXP
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis MDM4/MDMX Inhibitor
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 p53+/+ | Colon carcinoma | Carcinoma | IC50>100 μM | CCK-8 assay | 72 h | 1 |
| HCT 116 p53-/- | Colon carcinoma | Carcinoma | IC50>100 μM | CCK-8 assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity 17
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification X(12)=Peg2, polyethylene glycol; X(15)=Hyp, hydroxyproline; X(17)=Hle, homoleucine
Chiral L
Physicochemical Information
Formula C85H112N16O20
Absent amino acids CDGHIKMNQRV
Common amino acids ALX
Mass 231132
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 8
Net charge -1
Boman Index 904
Hydrophobicity 48.33
Aliphatic Index 81.67
Half Life
/
Extinction Coefficient cystines 8480
Absorbance 280nm 498.82
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36185610
Title Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.