PMI-HIF1-3

General Information


DRACP ID  DRACP05910

Peptide Name   PMI-HIF1-3

Sequence  TSFAEYWALLSXLAXYXP

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Induce apoptosis MDM5/MDMX Inhibitor



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HCT 116 p53+/+ Colon carcinoma Carcinoma IC50>100 μM CCK-8 assay 72 h 1
HCT 116 p53-/- Colon carcinoma Carcinoma IC50>100 μM CCK-8 assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2, MDMX

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  17

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  X(12)=Peg3, polyethylene glycol; X(15)=Hyp, hydroxyproline; X(17)=Hle, homoleucine

Chiral  L



Physicochemical Information


Formula  C85H112N16O20

Absent amino acids  CDGHIKMNQRV

Common amino acids  ALX

Mass  231132

Pl  3.85

Basic residues  0

Acidic residues  1

Hydrophobic residues  8

Net charge  -1

Boman Index  904

Hydrophobicity  48.33

Aliphatic Index  81.67

Half Life 
  /

Extinction Coefficient cystines  8480

Absorbance 280nm  498.82

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36185610

Title  Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression

Doi 10.7150/thno.75444

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.