SPMI1

General Information


DRACP ID  DRACP05917

Peptide Name   SPMI1

Sequence  TSFⓍEYWⓍLLS

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Induce apoptosis Induce cell cycle arrest MDM6/MDMX Inhibitor



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HCT 116 p53+/+ Colon carcinoma Carcinoma IC50>100 μM CCK-8 assay 72 h 1
HCT 116 p53-/- Colon carcinoma Carcinoma IC50>100 μM CCK-8 assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2, MDMX

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  4

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Ⓧ=S-pentenyl-alanine

Chiral  L



Physicochemical Information


Formula  C56H72N10O14

Absent amino acids  ACDGHIKMNPQRV

Common amino acids  LS

Mass  128778

Pl  3.85

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  -117

Hydrophobicity  21.82

Aliphatic Index  70.91

Half Life 
  /

Extinction Coefficient cystines  6990

Absorbance 280nm  699

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36185610

Title  Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression

Doi 10.7150/thno.75444

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.