Peptide Libraray

P2shortA

General Information

DRACP ID DRACP05919

Peptide Name P2shortA

Sequence ALPISTVRⓍVALⓍRRL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Induce apoptosis Induce cell cycle arrest MDM6/MDMX Inhibitor

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	50% Killing=10 μM	Crystal violet dye	24, 48 or 72 h	1
PC-9	Lung adenocarcinoma	Carcinoma	80% Killing=10 μM	Crystal violet dye	24, 48 or 72 h	1
NCI-H358	Minimally invasive lung adenocarcinoma	Carcinoma	98% Killing=10 μM	Crystal violet dye	24, 48 or 72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity 74

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification Ⓧ=(S)-pentenylalanine

Chiral L

Physicochemical Information

Formula C70H125N23O15

Absent amino acids CDEFGHKMNQWY

Common amino acids LR

Mass 179664

Pl 12.8

Basic residues 3

Acidic residues 0

Hydrophobic residues 8

Net charge 3

Boman Index -1935

Hydrophobicity 70.63

Aliphatic Index 146.25

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32104498

Title Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth

Doi 0.7150/thno.40971

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available