This work is licensed under a Creative Commons Attribution 4.0 International License.
LHP2
General Information
DRACP ID DRACP05921
Peptide Name LHP2
Sequence FRRKAFLHWYTG
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Tubulin Inhibitors
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=271.59 ± 76.41 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Tubulin
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond
N-terminal Modification FITC, 5(6)-carboxy fluorescence
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C77H108N22O15
Absent amino acids CDEIMNPQSV
Common amino acids FR
Mass 177822
Pl 11.53
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -2680
Hydrophobicity -68.33
Aliphatic Index 40.83
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36240440
Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
Doi 0.1021/acs.jmedchem.2c01116
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.