LHP4

General Information


DRACP ID  DRACP05923

Peptide Name   LHP4

Sequence  VPELTQQMF

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Tubulin Inhibitors



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Tubulin

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  FITC, 5(6)-carboxy fluorescence

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C49H77N11O15S

Absent amino acids  ACDGHIKNRSWY

Common amino acids  Q

Mass  123515

Pl  3.85

Basic residues  0

Acidic residues  1

Hydrophobic residues  3

Net charge  -1

Boman Index  -617

Hydrophobicity  -1.11

Aliphatic Index  75.56

Half Life 
  Mammalian: 100 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36240440

Title  Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors

Doi 0.1021/acs.jmedchem.2c01116

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.