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SHP1
General Information
DRACP ID DRACP05925
Peptide Name SHP1
Sequence TEXQTNXVP
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis Tubulin Inhibitors
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Tubulin
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(3) and Ⓧ (7) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC, 5(6)-carboxy fluorescence
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl) Ala
Chiral L
Physicochemical Information
Formula C32H49N9O12
Absent amino acids ACDFGHIKLMRSWY
Common amino acids TX
Mass 111466
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 1
Net charge -1
Boman Index -2009
Hydrophobicity -103.33
Aliphatic Index 32.22
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36240440
Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
Doi 0.1021/acs.jmedchem.2c01116
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.