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SHP5
General Information
DRACP ID DRACP05929
Peptide Name SHP5
Sequence NEAⓍYDIⓍFR
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis Tubulin Inhibitors
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Tubulin
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC, 5(6)-carboxy fluorescence
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl) Ala
Chiral L
Physicochemical Information
Formula C46H62N12O13
Absent amino acids CGHKLMPQSTVW
Common amino acids ADEFINRY
Mass 115178
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 3
Net charge -1
Boman Index -2752
Hydrophobicity -72
Aliphatic Index 49
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36240440
Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
Doi 0.1021/acs.jmedchem.2c01116
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.