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ISHP2
General Information
DRACP ID DRACP05933
Peptide Name ISHP2
Sequence XRRKAFⓍHWYⓍG
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce apoptosis Tubulin Inhibitors
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=52.33 ± 3.75 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Tubulin
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC, 5(6)-carboxy fluorescence
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl) Ala; X=Phe-I (para-Halo phenylalanine)
Chiral L
Physicochemical Information
Formula C58H75N19O8
Absent amino acids CDEILMNPQSTV
Common amino acids R
Mass 147273
Pl 11.53
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index -3213
Hydrophobicity -117.5
Aliphatic Index 8.33
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36240440
Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
Doi 0.1021/acs.jmedchem.2c01116
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.