This work is licensed under a Creative Commons Attribution 4.0 International License.
SAHPA1
General Information
DRACP ID DRACP05934
Peptide Name SAHPA1
Sequence PQRⓍILDQHVⓍRVMK
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin degrader
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Not available
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity 34
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(3) and Ⓧ (10) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(3)=R8; Ⓧ(10)=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C70H118N24O16S
Absent amino acids ACEFGNSTWY
Common amino acids QRV
Mass 183382
Pl 11.48
Basic residues 4
Acidic residues 1
Hydrophobic residues 4
Net charge 3
Boman Index -3958
Hydrophobicity -64
Aliphatic Index 90.67
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32550000
Title A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Year 2020
Literature 2
Pubmed ID 23439249
Title Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.