This work is licensed under a Creative Commons Attribution 4.0 International License.
SAHPA1-VHLL
General Information
DRACP ID DRACP05935
Peptide Name SAHPA1-VHLL
Sequence PQRⓍILDQHVⓍRVMKXALAPYIP
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin degrader
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Not available
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(3) and Ⓧ (10) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(3)=R8; Ⓧ(10)=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C107H171N31O23S
Absent amino acids CEFGNSTW
Common amino acids P
Mass 279439
Pl 10.45
Basic residues 4
Acidic residues 1
Hydrophobic residues 8
Net charge 3
Boman Index -2626
Hydrophobicity -9.57
Aliphatic Index 101.74
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 67.73
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32550000
Title A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.