This work is licensed under a Creative Commons Attribution 4.0 International License.
xStAx, aStAx-35R
General Information
DRACP ID DRACP05936
Peptide Name xStAx, aStAx-35R
Sequence RRWPRⓍILDⓍHVRRVWR
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin degrader
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Not available
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C95H149N37O16
Absent amino acids ACEFGKMNQSTY
Common amino acids R
Mass 235102
Pl 12.8
Basic residues 7
Acidic residues 1
Hydrophobic residues 6
Net charge 6
Boman Index -8032
Hydrophobicity -120
Aliphatic Index 80
Half Life
/
Extinction Coefficient cystines 11000
Absorbance 280nm 687.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32550000
Title A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Year 2020
Literature 2
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.