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xStAx-VHLL
General Information
DRACP ID DRACP05937
Peptide Name xStAx-VHLL
Sequence RRWPRⓍlLDⓍHVRRVWRXALAPYIP
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin degrader
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Not available
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral Mix
Physicochemical Information
Formula C126H189N43O21
Absent amino acids CEFGKMNQST
Common amino acids R
Mass 318041
Pl 12.5
Basic residues 7
Acidic residues 1
Hydrophobic residues 9
Net charge 6
Boman Index -7192
Hydrophobicity -70
Aliphatic Index 78
Half Life
/
Extinction Coefficient cystines 12490
Absorbance 280nm 520.42
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32550000
Title A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.