This work is licensed under a Creative Commons Attribution 4.0 International License.
fAxWT
General Information
DRACP ID DRACP05938
Peptide Name fAxWT
Sequence BENPESILDEHVQRVM
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=~5 μM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity 15
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification B=β-Ala
Chiral L
Physicochemical Information
Formula C75H120N22O26S
Absent amino acids ACFGKTWY
Common amino acids E
Mass 204570
Pl 4.15
Basic residues 2
Acidic residues 4
Hydrophobic residues 4
Net charge -2
Boman Index -4404
Hydrophobicity -78.13
Aliphatic Index 85
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.