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fStAx-1
General Information
DRACP ID DRACP05939
Peptide Name fStAx-1
Sequence BENPEⓍILDEHVⓍRVM
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=~3 μM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity 9
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification B=β-Ala; Ⓧ(6)=(R)-2-(7’-octenyl)alanine; Ⓧ(13)=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C67H103N19O20S
Absent amino acids ACFGKQSTWY
Common amino acids E
Mass 179446
Pl 4.15
Basic residues 2
Acidic residues 4
Hydrophobic residues 4
Net charge -2
Boman Index -3510
Hydrophobicity -51.25
Aliphatic Index 85
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.