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fStAx-2
General Information
DRACP ID DRACP05940
Peptide Name fStAx-2
Sequence BENPESILDⓍHVQⓍVM
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=~4 μM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity 33
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(10) and Ⓧ (14) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification B=β-Ala; Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C64H97N17O20S
Absent amino acids ACFGKRTWY
Common amino acids EV
Mass 172437
Pl 3.93
Basic residues 1
Acidic residues 3
Hydrophobic residues 4
Net charge -2
Boman Index -2231
Hydrophobicity -28.13
Aliphatic Index 85
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.