This work is licensed under a Creative Commons Attribution 4.0 International License.
fStAx-3
General Information
DRACP ID DRACP05941
Peptide Name fStAx-3
Sequence BENPEⓍILDⓍHVQRVM
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=60±2 nM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity 51
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification B=β-Ala; Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C67H104N20O19S
Absent amino acids ACFGKSTWY
Common amino acids EV
Mass 179348
Pl 4.42
Basic residues 2
Acidic residues 3
Hydrophobic residues 4
Net charge -1
Boman Index -3383
Hydrophobicity -51.25
Aliphatic Index 85
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.