This work is licensed under a Creative Commons Attribution 4.0 International License.
fStAx-32
General Information
DRACP ID DRACP05943
Peptide Name fStAx-32
Sequence XPQⓍILDⓍHVRRVMR
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=132±12 nM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification X=PEG1, [2-(2-aminoethoxy)ethoxy]acetyl; Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C65H108N24O13S
Absent amino acids ACEFGKNSTWY
Common amino acids R
Mass 182568
Pl 12.2
Basic residues 4
Acidic residues 1
Hydrophobic residues 4
Net charge 3
Boman Index -4341
Hydrophobicity -44.67
Aliphatic Index 90.67
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.