This work is licensed under a Creative Commons Attribution 4.0 International License.
fStAx-33
General Information
DRACP ID DRACP05944
Peptide Name fStAx-33
Sequence XPQⓍILDⓍHVRRVWR
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=16±2 nM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification X=PEG1, [2-(2-aminoethoxy)ethoxy]acetyl; Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C71H109N25O13
Absent amino acids ACEFGKMNSTY
Common amino acids R
Mass 188070
Pl 12.2
Basic residues 4
Acidic residues 1
Hydrophobic residues 5
Net charge 3
Boman Index -4343
Hydrophobicity -63.33
Aliphatic Index 90.67
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.