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fStAx-40
General Information
DRACP ID DRACP05948
Peptide Name fStAx-40
Sequence XRRWPQⓍILHⓍDVRRVWR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides β-catenin inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target β-catenin
Affinity Kd=~4 μM
Mechanism Inhibit wnt/β-catenin signaling pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
N-terminal Modification FITC
C-terminal Modification Amidation
Other Modification X=PEG1, [2-(2-aminoethoxy)ethoxy]acetyl; Ⓧ=(S)-2-(4'-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C94H143N35O16
Absent amino acids ACEFGKMNSTY
Common amino acids R
Mass 243279
Pl 12.68
Basic residues 6
Acidic residues 1
Hydrophobic residues 6
Net charge 5
Boman Index -7094
Hydrophobicity -107.78
Aliphatic Index 75.56
Half Life
/
Extinction Coefficient cystines 11000
Absorbance 280nm 647.06
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23071338
Title Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.