fStAx-41R

General Information


DRACP ID  DRACP05950

Peptide Name   fStAx-41R

Sequence  XRRWPRⓍILHⓍDVRRVAR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides β-catenin inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  β-catenin

Affinity  Kd>10 μM

Mechanism  Inhibit wnt/β-catenin signaling pathway

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling

N-terminal Modification  FITC

C-terminal Modification 

Other Modification  X=PEG1, [2-(2-aminoethoxy)ethoxy]acetyl; Ⓧ=(S)-2-(4'-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  C87H142N36O15

Absent amino acids  CEFGKMNQSTY

Common amino acids  R

Mass  234571

Pl  12.8

Basic residues  7

Acidic residues  1

Hydrophobic residues  6

Net charge  6

Boman Index  -8084

Hydrophobicity  -98.33

Aliphatic Index  81.11

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  323.53

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23071338

Title  Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Doi 10.1073/pnas.1208396109

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.