aStAx-41R

General Information


DRACP ID  DRACP05952

Peptide Name   aStAx-41R

Sequence  RRWPRⓍILHⓍDVRRVAR

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides β-catenin inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  β-catenin

Affinity  Not available

Mechanism  Inhibit wnt/β-catenin signaling pathway

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C87H144N36O16

Absent amino acids  CEFGKMNQSTY

Common amino acids  R

Mass  223589

Pl  12.8

Basic residues  7

Acidic residues  1

Hydrophobic residues  6

Net charge  6

Boman Index  -8084

Hydrophobicity  -104.12

Aliphatic Index  85.88

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  343.75

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23071338

Title  Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Doi 10.1073/pnas.1208396109

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.