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StRIP8
General Information
DRACP ID DRACP05960
Peptide Name StRIP8
Sequence DDEⓍEQFⓍYHLXSFNXV
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Rab8a GTPase
Affinity rel.Kd=1.36 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*
* Cmax[Rab8a6-176(GppNHp)]=300 µM, Kd(StRIP3)=13.2 µM
Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling
N-terminal Modification Fluorescein-O2OC-
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine; X=Leu-OMe
Chiral L
Physicochemical Information
Formula C74H91N17O22
Absent amino acids ACGIKMPRTW
Common amino acids DEFX
Mass 207620
Pl 3.74
Basic residues 1
Acidic residues 4
Hydrophobic residues 4
Net charge -3
Boman Index -3652
Hydrophobicity -74.71
Aliphatic Index 40
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 93.13
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27336832
Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.