StRIP14[E902Q,E904Q]
General Information
DRACP ID DRACP05983
Peptide Name StRIP14[E902Q,E904Q]
Sequence DDQⓍQWFⓍYHLⓍFFNⓍV
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Rab8a GTPase
Affinity rel.Kd=0.78 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*
* Cmax[Rab8a6-176(GppNHp)]=570 µM, Kd(StRIP3)=64.16 µM
Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling
N-terminal Modification Fluorescein-O2OC-
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C86H99N19O18
Absent amino acids ACEGIKMPRST
Common amino acids F
Mass 197242
Pl 4.11
Basic residues 1
Acidic residues 2
Hydrophobic residues 6
Net charge -1
Boman Index -1973
Hydrophobicity -38.24
Aliphatic Index 40
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 436.88
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27336832
Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available