StRIP14[D900N,E902Q,E904Q]

General Information


DRACP ID  DRACP05985

Peptide Name   StRIP14[D900N,E902Q,E904Q]

Sequence  NDQⓍQWFⓍYHLⓍFFNⓍV

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Rab8a GTPase

Affinity  rel.Kd=0.8 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*

*  Cmax[Rab8a6-176(GppNHp)]=570 µM, Kd(StRIP3)=64.18 µM

Mechanism  Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling

N-terminal Modification  Fluorescein-O2OC-

C-terminal Modification  Free

Other Modification  Ⓧ=(S)-2-(4-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  C86H100N20O17

Absent amino acids  ACEGIKMPRST

Common amino acids  F

Mass  197143

Pl  5.29

Basic residues  1

Acidic residues  1

Hydrophobic residues  6

Net charge  0

Boman Index  -1765

Hydrophobicity  -38.24

Aliphatic Index  40

Half Life 
  /

Extinction Coefficient cystines  6990

Absorbance 280nm  436.88

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27336832

Title  Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

Doi 2016

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.