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StRIP14[D900N,D901N,E904Q]
General Information
DRACP ID DRACP05986
Peptide Name StRIP14[D900N,D901N,E904Q]
Sequence NNEⓍQWFⓍYHLⓍFFNⓍV
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Rab8a GTPase
Affinity rel.Kd=0.8 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*
* Cmax[Rab8a6-176(GppNHp)]=570 µM, Kd(StRIP3)=64.19 µM
Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling
N-terminal Modification Fluorescein-O2OC-
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C86H100N20O17
Absent amino acids ACDGIKMPRST
Common amino acids FN
Mass 197142
Pl 5.36
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -1684
Hydrophobicity -38.24
Aliphatic Index 40
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 436.88
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27336832
Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.