SAH-p53-5

General Information


DRACP ID  DRACP05993

Peptide Name   SAH-p53-5

Sequence  LSQETFⓍNLWKLLⓍQN

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Mdm2 inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Mdm2

Affinity  Kd=0.8 nM

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Ⓧ(7)=R8; Ⓧ(14)=S6

Chiral  L



Physicochemical Information


Formula  C80H120N20O21

Absent amino acids  ACDGHIMPRVY

Common amino acids  L

Mass  196569

Pl  6.41

Basic residues  1

Acidic residues  1

Hydrophobic residues  6

Net charge  0

Boman Index  -1770

Hydrophobicity  -36.25

Aliphatic Index  97.5

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  366.67

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22148351

Title  Structure of the stapled p53 peptide bound to Mdm2

Doi 10.1021/ja2090367

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.