This work is licensed under a Creative Commons Attribution 4.0 International License.
SAH-p53-5
General Information
DRACP ID DRACP05993
Peptide Name SAH-p53-5
Sequence LSQETFⓍNLWKLLⓍQN
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Mdm2 inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Mdm2
Affinity Kd=0.8 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Free
Other Modification Ⓧ(7)=R8; Ⓧ(14)=S6
Chiral L
Physicochemical Information
Formula C80H120N20O21
Absent amino acids ACDGHIMPRVY
Common amino acids L
Mass 196569
Pl 6.41
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -1770
Hydrophobicity -36.25
Aliphatic Index 97.5
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22148351
Title Structure of the stapled p53 peptide bound to Mdm2
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.