This work is licensed under a Creative Commons Attribution 4.0 International License.
5
General Information
DRACP ID DRACP05998
Peptide Name 5
Sequence FETLRGDLRILSILRⓍQNLⓍKELQD
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from chromogranin A)
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides αvβ6/αvβ8 inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target αvβ6, αvβ8
Affinity αvβ6: Ki=0.6 ± 0.1 nM; αvβ8: Ki=3.2 ± 1.2 nM
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(16) and Ⓧ (20) are cross-linked by triazole bridge stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(16)=Propargylglycine; Ⓧ(20)=Azidolysine
Chiral L
Physicochemical Information
Formula C122H204N36O35
Absent amino acids ACHMPVWY
Common amino acids L
Mass 316346
Pl 6.63
Basic residues 4
Acidic residues 4
Hydrophobic residues 9
Net charge 0
Boman Index -6178
Hydrophobicity -36.8
Aliphatic Index 124.8
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36594095
Title A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.