This work is licensed under a Creative Commons Attribution 4.0 International License.
GexIVA[1,4]
General Information
DRACP ID DRACP06191
Peptide Name GexIVA[1,4]
Sequence TCRSSGRYCRSPYDRRRRYCRRITDACV
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Alpha O-conotoxin
Type Native peptide
Classification
Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50=16 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys27; Cys9<--->Cys20
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H231N55O41S4
Absent amino acids EFHKLMNQW
Common amino acids R
Mass 393869
Pl 10.4
Basic residues 9
Acidic residues 2
Hydrophobic residues 3
Net charge 7
Boman Index -15065
Hydrophobicity -131.07
Aliphatic Index 27.86
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4720
Absorbance 280nm 174.81
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010959A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.