GexIVA[1,4]

General Information


DRACP ID  DRACP06191

Peptide Name   GexIVA[1,4]

Sequence  TCRSSGRYCRSPYDRRRRYCRRITDACV

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Alpha O-conotoxin

Type  Native peptide

Classification

  

Cancer targeted peptides α9α10nAChR inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α9α10nAChR

Affinity  IC50=16 nM (Blocking α9α10nAChR)

Mechanism  Specifically block the α9α10nAChR

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys27; Cys9<--->Cys20

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C139H231N55O41S4

Absent amino acids  EFHKLMNQW

Common amino acids  R

Mass  393869

Pl  10.4

Basic residues  9

Acidic residues  2

Hydrophobic residues  3

Net charge  7

Boman Index  -15065

Hydrophobicity  -131.07

Aliphatic Index  27.86

Half Life 
  Mammalian: 7.2 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  4720

Absorbance 280nm  174.81

Polar residues  13

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN112010959A

Patent Title  Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.