This work is licensed under a Creative Commons Attribution 4.0 International License.
[R15A/R16A/R17A/R18A]GeXIVA[1,2]
General Information
DRACP ID DRACP06216
Peptide Name [R15A/R16A/R17A/R18A]GeXIVA[1,2]
Sequence TCRSSGRYCRSPYDAAAAYCRRITDACV
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50>10000 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys9; Cys20<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H203N43O41S4
Absent amino acids EFHKLMNQW
Common amino acids AR
Mass 359829
Pl 8.66
Basic residues 5
Acidic residues 2
Hydrophobic residues 7
Net charge 3
Boman Index -8373
Hydrophobicity -41.07
Aliphatic Index 42.14
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4720
Absorbance 280nm 174.81
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010959A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.