This work is licensed under a Creative Commons Attribution 4.0 International License.
Δ6-22GeXIVA
General Information
DRACP ID DRACP06228
Peptide Name Δ6-22GeXIVA
Sequence GRYCRSPYDRRRRYCRR
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50=14 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys15
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H155N41O24S2
Absent amino acids AEFHIKLMNQTVW
Common amino acids R
Mass 260519
Pl 11.69
Basic residues 8
Acidic residues 1
Hydrophobic residues 0
Net charge 7
Boman Index -12840
Hydrophobicity -242.35
Aliphatic Index 0
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4595
Absorbance 280nm 287.19
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010960A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.