This work is licensed under a Creative Commons Attribution 4.0 International License.
[C2A, C9A]GeXIVA
General Information
DRACP ID DRACP06243
Peptide Name [C2A, C9A]GeXIVA
Sequence TARSSGRYARSPYDRRRRYCRRITDACV
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50=16 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys20<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H231N55O41S2
Absent amino acids EFHKLMNQW
Common amino acids R
Mass 387457
Pl 11.64
Basic residues 9
Acidic residues 2
Hydrophobic residues 5
Net charge 7
Boman Index -14959
Hydrophobicity -136.07
Aliphatic Index 35
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 4595
Absorbance 280nm 170.19
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010972A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.