[C2S, C9S, C20S, C27S]GeXIVA

General Information


DRACP ID  DRACP06252

Peptide Name   [C2S, C9S, C20S, C27S]GeXIVA

Sequence  TSRSSGRYSRSPYDRRRRYSRRITDASV

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides α9α10nAChR inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α9α10nAChR

Affinity  IC50=16 nM (Blocking α9α10nAChR)

Mechanism  Specifically block the α9α10nAChR

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C139H231N55O45

Absent amino acids  CEFHKLMNQW

Common amino acids  R

Mass  387441

Pl  12.2

Basic residues  9

Acidic residues  2

Hydrophobic residues  3

Net charge  7

Boman Index  -16937

Hydrophobicity  -178.21

Aliphatic Index  27.86

Half Life 
  Mammalian: 7.2 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  4470

Absorbance 280nm  165.56

Polar residues  13

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN112010972A

Patent Title  Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.