This work is licensed under a Creative Commons Attribution 4.0 International License.
GeFlex-GeXIVA
General Information
DRACP ID DRACP06261
Peptide Name GeFlex-GeXIVA
Sequence tCrSSGrYCrSPYDrrrrYCrrITDACv
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50=24.53 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys9; Cys20<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula C76H85N17O18S4
Absent amino acids EFHKLMNQRVW
Common amino acids C
Mass 213462
Pl 3.49
Basic residues 0
Acidic residues 2
Hydrophobic residues 2
Net charge -2
Boman Index -1784
Hydrophobicity 1.07
Aliphatic Index 17.5
Half Life
/
Extinction Coefficient cystines 4720
Absorbance 280nm 174.81
Polar residues 12
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010972A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.