Bombesin
DRACPC ID DRACPC0078
Active Ingredients Bombesin
Description A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Synonyms Bombesin
Type Small Molecule
Disease Prostate Cancer
Classification
Peptide and derivative
Structure Information
Molecular Formula C71H110N24O18S
Molecular Weight 1619.9
Active Sequence XQRLGNQWAVGHLM
Sequence Length 14
Modification X=Pyr, N-terminal NH2
IUPAC Name (2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-4-carbamoyl-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamido]pentanamido]-4-methylpentanamido]acetamido}-3-carbamoylpropanamido]-N-[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-methylpropyl]carbamoyl}ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]pentanediamide
InChI InChI=1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1
InChI_Key QXZBMSIDSOZZHK-DOPDSADYSA-N
SMILES NC(CC[C@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N1)CCC1=O)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)CC(N)=O)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)=O)C(C)C)=O)=O)CC3=CNC4=CC=CC=C43)=O)=O
External Codes
PubChem CID 16201612
DrugBank Accession Number DB11724
NCI Thesaurus Code C315
UNII PX9AZU7QPK GSRS
CAS 31362-50-2
Drug approval
Drug indication
Investigated for use/treatment in Prostate Cancer.
The drug is not approved.
| ClinicalTrials.gov Identifier | Title | Condition or disease | Phase | Purpose |
|---|---|---|---|---|
| NCT02440308 | 68Ga-DOTA-Bombesin PET/MRI in the Evaluation of Patients With Prostate Cancer: A Feasibility Study | Prostate Carcinoma | Phase 2 | Diagnostic |
| NCT03724253 | Phase II Study of Preliminary Diagnostic Performance of [68Ga]-NeoBOMB1 in Adult Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR) | Breast Cancer; Prostate Cancer; Colorectal Cancer; Non Small Cell Lung Cancer; Small Cell Lung Cancer | Phase 2 | Diagnostic |
More clinical information is obtained from ClinicalTrials.gov.
