This work is licensed under a Creative Commons Attribution 4.0 International License.
LfcinB (20–30)4
General Information
DRACP ID DRACP00791
Peptide Name LfcinB (20–30)4
Sequence RWQWRMKKLGRWQWRMKKLGKXC [Precursor of tetrameric peptide]
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Bovine Lactoferricin
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-468 | Breast adenocarcinoma | Carcinoma | IC50=2 μM | MTT assay | 2h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=6 μM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Ahx
Chiral L
Physicochemical Information
Formula C137H215N45O24S3
Absent amino acids ADEFHINPSTVY
Common amino acids K
Mass 347527
Pl 12.54
Basic residues 9
Acidic residues 0
Hydrophobic residues 6
Net charge 9
Boman Index -7149
Hydrophobicity -152.17
Aliphatic Index 33.91
Half Life
/
Extinction Coefficient cystines 22000
Absorbance 280nm 1000
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28961215
Title Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.