This work is licensed under a Creative Commons Attribution 4.0 International License.
LfcinB (17-31)
General Information
DRACP ID DRACP00792
Peptide Name LfcinB (17-31)
Sequence FKARRWQWRMKKLGA
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Bovine Lactoferricin
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-468 | Breast adenocarcinoma | Carcinoma | IC50>102 μM | MTT assay | 2h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50>102 μM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C91H144N30O17S
Absent amino acids CDEHINPSTVY
Common amino acids KR
Mass 221229
Pl 12.82
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -4748
Hydrophobicity -125.33
Aliphatic Index 39.33
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 785.71
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28961215
Title Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.