This work is licensed under a Creative Commons Attribution 4.0 International License.
LfcinB (20–30)cyc
General Information
DRACP ID DRACP00797
Peptide Name LfcinB (20–30)cyc
Sequence CRWQWRMKKLGXC
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Bovine Lactoferricin
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-468 | Breast adenocarcinoma | Carcinoma | IC50>107 μM | MTT assay | 2h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=7 μM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys1<--->Cys13
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Ahx
Chiral L
Physicochemical Information
Formula C70H109N23O13S3
Absent amino acids ADEFHINPSTVY
Common amino acids CKRW
Mass 190119
Pl 10.78
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index -3105
Hydrophobicity -90.77
Aliphatic Index 30
Half Life
/
Extinction Coefficient cystines 11125
Absorbance 280nm 927.08
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28961215
Title Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.