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B18KA
General Information
DRACP ID DRACP01015
Peptide Name B18KA
Sequence GFQKVKAQALTCLHTVMA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-468 | Breast adenocarcinoma | Carcinoma | IC50=135.6±9.3 µM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=83.7±20.1 µM | MTT assay | 24h | 1 |
| ZR-75-1 | Invasive breast carcinoma of no special type | Carcinoma | IC50=58.9±2.0 µM | MTT assay | 24h | 1 |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50=78.5±20.9 µM | MTT assay | 24h | 1 |
| SK-BR-3 | Breast adenocarcinoma | Carcinoma | IC50=43.5±11.5 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=61.8±3.9 µM | MTT assay | 24h | 1 |
| MCF-7/G11-TR1 | Breast cancer | Carcinoma | IC50=61.8±5.1 µM | MTT assay | 24h | 1 |
| MCF-7/G11-TR5 | Breast cancer | Carcinoma | IC50=56.4±5.0 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity IC50 on PBMCs was = 92.0 ± 39.6 μM
Target Not available
Affinity Not available
Mechanism may induce cell death through processes involving membrane surface blebs, loss of membrane integrity, PI internalization, LDH release and PS externalization, coupled with coordinated regulation of Src•Erk1/18 signaling and mitochondrial events.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C86H144N24O23S2
Absent amino acids DEINPRSWY
Common amino acids A
Mass 224979
Pl 9.68
Basic residues 3
Acidic residues 0
Hydrophobic residues 8
Net charge 3
Boman Index -108
Hydrophobicity 48.89
Aliphatic Index 92.22
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32872253
Title Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.