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B18I
General Information
DRACP ID DRACP01017
Peptide Name B18I
Sequence GIGKAIAKAIACIAKAIA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-468 | Breast adenocarcinoma | Carcinoma | IC50=16.6±1.5 µM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=18.6±2.4 µM | MTT assay | 24h | 1 |
| ZR-75-1 | Invasive breast carcinoma of no special type | Carcinoma | IC50=10.1±1.8 µM | MTT assay | 24h | 1 |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50 >148.5 µM | MTT assay | 24h | 1 |
| SK-BR-3 | Breast adenocarcinoma | Carcinoma | IC50=18.1±4.7 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=16.0±1.6 µM | MTT assay | 24h | 1 |
| MCF-7/G11-TR1 | Breast cancer | Carcinoma | IC50=10.8±2.0 µM | MTT assay | 24h | 1 |
| MCF-7/G11-TR5 | Breast cancer | Carcinoma | IC50=16.1±4.9 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity IC50 on PBMCs was = 92.0 ± 39.6 μM
Target Not available
Affinity Not available
Mechanism may induce cell death through processes involving membrane surface blebs, loss of membrane integrity, PI internalization, LDH release and PS externalization, coupled with coordinated regulation of Src•Erk1/34 signaling and mitochondrial events.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C76H139N21O19S
Absent amino acids DEFHLMNPQRSTVWY
Common amino acids A
Mass 198659
Pl 10.51
Basic residues 3
Acidic residues 0
Hydrophobic residues 12
Net charge 3
Boman Index 2378
Hydrophobicity 139.44
Aliphatic Index 147.22
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32872253
Title Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.