B18L

General Information


DRACP ID  DRACP01018

Peptide Name   B18L

Sequence  GLGKALAKALACLAKALA

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-468 Breast adenocarcinoma Carcinoma IC50=12.4±1.4 µM MTT assay 24h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=7.2±0.8 µM MTT assay 24h 1
ZR-75-1 Invasive breast carcinoma of no special type Carcinoma IC50=5.2±1.0 µM MTT assay 24h 1
T-47D Invasive breast carcinoma of no special type Carcinoma IC50=17.5±6.5 µM MTT assay 24h 1
SK-BR-3 Breast adenocarcinoma Carcinoma IC50=7.2±1.0 µM MTT assay 24h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=5.9±0.5 µM MTT assay 24h 1
MCF-7/G11-TR1 Breast cancer Carcinoma IC50=6.2±0.8 µM MTT assay 24h 1
MCF-7/G11-TR5 Breast cancer Carcinoma IC50=3.8±0.3 µM MTT assay 24h 1

Hemolytic Activity  Human red blood cells: EC 50=21.2±3.2 μM, testing time is 24 h

Normal (non-cancerous) Cytotoxicity  IC50 on PBMCs was = 92.0 ± 39.6 μM

Target  Not available

Affinity  Not available

Mechanism  may induce cell death through processes involving membrane surface blebs, loss of membrane integrity, PI internalization, LDH release and PS externalization, coupled with coordinated regulation of Src•Erk1/26 signaling and mitochondrial events.

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01018

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C76H139N21O19S

Absent amino acids  DEFHIMNPQRSTVWY

Common amino acids  A

Mass  198659

Pl  10.51

Basic residues  3

Acidic residues  0

Hydrophobic residues  12

Net charge  3

Boman Index  2378

Hydrophobicity  120

Aliphatic Index  147.22

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32872253

Title  Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead

Doi 10.3390/cancers12092448

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.